Epub 2023 Jan 12. Pseudogenes: 539 to 682. The UCSC genome browser database: 2019 update. "Finishing the Euchromatic Sequence of the Human Genome," Nature 431, 931-945.] The results can serve as a reference for researchers interested in expression profiles of human cell lines at both the disease level and cell line level. Pseudogenes: 606 to 879. Coding Region Position: hg38 chr20:63,488,023-63,497,763 Size: 9,741 Coding . Non-coding RNA genes: 323 to 622 Non-coding RNA genes: 242 to 1,052 FLH176500.01L; RZPDo839E01121D eukaryotic translation elongation factor 1 alpha 2 (EEF1A2) gene, encodes complete protein. doi: 10.1093/dnares/dsv028. Pseudogenes: 761 to 902. First, the data are now updated as of January 2019 rather than January 2016, exploiting novel information made available in the last 3years and thus showing how some parameters have been subjected to relevant changes, while others appear to be stable. [Analysis, identification and correction of some errors of model refseqs appeared in NCBI Human Gene Database by in silico cloning and experimental verification of novel human genes]. Through comparative analyses with the cell-type-specific gene expression data in Arabidopsis roots [ 8 ], we identified co-expression gene-regulatory networks (GRNs) conserved in Arabidopsis and radish roots. Correlation analysis based on mRNA expression levels of human genes in cancer tissue and the clinical outcome for almost 8000 cancer patients is presented in a gene-centric manner. Non-coding RNA genes: 246 to 830 Unable to load your collection due to an error, Unable to load your delegates due to an error. The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria.These are usually treated separately as the nuclear genome and the mitochondrial genome. Terms and Conditions, Piovesan A, Caracausi M, Ricci M, Strippoli P, Vitale L, Pelleri MC. When expanded it provides a list of search options that will switch the search inputs to match the current selection. 2017-05-19 List of genes. . Using the spreadsheet filtering and summarization functions (Excel for Mac 2011, Microsoft) or exploiting the search and calculation functions in GeneBase (FileMaker Pro) provided identical results in all cases. KJ901729 - Synthetic construct Homo sapiens clone ccsbBroadEn_11123 CCL25 gene, encodes complete protein. The genes in chromosome 2 span 242 million nucleotide base pairs, which also amounts to about 8% of the human DNA. 2004. 2019;47:D853D858. Bethesda, MD 20894, Web Policies While the basic approach to obtain the data we present here is similar to the one followed in our previous study about the subject [6], there are two main differences. 17 January 2023, Mammalian Genome 2008;3:20. Human protein-coding genes and gene feature statistics in 2019. Strittmatter, W. J. et al. Other parameters such as gene, exon or intron mean and extreme length appear to have reached a stability that is unlikely to be substantially modified by human genome data updates, at least regarding protein-coding genes. DNA Res. Nature 312, 767768 (1984). 22 June 2021, Receive 51 print issues and online access, Get just this article for as long as you need it, Prices may be subject to local taxes which are calculated during checkout. The transcriptomics analysis covers 1055 human cell lines, corresponding to 27 cancer types, one non-cancerous group and one uncategorised group of cellines, and includes classification based on specificity, distribution and expression clusters. The data are updated as of January 2019, 3years after the last published analysis of human gene features [6] and pre-filtered according to public annotation about the review or validation of the records to ensure reliability of the data. In order to provide reliable data, we focused on a curated subset of human nuclear protein-coding genes with a REVIEWED or VALIDATED Reference Sequence (RefSeq) status [1, 7]. PMC https://doi.org/10.1186/s13104-019-4343-8, DOI: https://doi.org/10.1186/s13104-019-4343-8. All authors critically discussed the final manuscript. The authors declare that they have no competing interests. For this, for each gene in a TCGA cohort, the FPKM values were averaged per cohort. So what are the Top Ten researched human genes? A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. "There are 3000 human . OLeary NA, Wright MW, Brister JR, Ciufo S, Haddad D, McVeigh R, Rajput B, Robbertse B, Smith-White B, Ako-Adjei D, et al. Pseudogenes: 458 to 566. Protein coding genes. The lists below constitute a complete list of all known human protein-coding genes. 2018;46:D813. Maddon, P. J. et al. Dalgleish, A. G. et al. In humans, these genes and accompanying molecules are coiled tightly inside 23 pairs of structures called chromosomes. doi: 10.1093/nar/gkx1095. Accounting between 5.5% and 6% of our DNA, chromosome 6 is the site of the Major Histocompatibility Complex, which is the critical for the bodys adaptive immune system. Although more than 90% of protein-coding genes in mouse have a 1:1 orthology relationship with a gene in human or rat, we also represent many-to-many 'orthology' relationships. If you continue, we'll assume that you are happy to receive all cookies. NB: Each list page contains 5000 human protein-coding genes, sorted alphanumerically by the, Learn how and when to remove this template message, List of human protein-coding genes page 1, List of human protein-coding genes page 2, List of human protein-coding genes page 3, List of human protein-coding genes page 4, Entrez-Cross Database Query Search System, https://en.wikipedia.org/w/index.php?title=Lists_of_human_genes&oldid=1095516146, This page was last edited on 28 June 2022, at 20:15. Non-coding RNA genes: 277 to 993 Pseudogenes: 703 to 933. The data presented in the Genes.xlsx, Transcripts.xlsx and Gene_Table.xlsx have been counter-checked with the complete, original data included in the GeneBase software. Open Access articles citing this article. Accounting for just one and a half percent of the human genome, chromosome 21 is infamous for its role in Down syndrome. National Library of Medicine Click "View all genes" to view a table of human genes. Gene structure in the sea urchin Strongylocentrotus purpuratus based on transcriptome analysis. PubMed Central The orange circles indicate the number of genes with enriched expression in a group of tissues, connected by lines. Non-coding RNA genes: 450 to 1,598 To obtain In addition, based on biological data mining, for each cell line, the relative activity of 14 cancer-related pathways and 43 cytokines were inferred and presented to characterize the phenotype of the cell line. If two predicted genes have been merged to form a new gene, both OLNs are indicated, separated by a slash. Genes contain nucleotides strands containing instructions on how to generate protein or RNA molecules. Non-coding RNA genes: 244 to 881 Pseudogenes: 513 to 598. Cell 42, 93104 (1985). Careers. Finally, a new classification has been introduced in which genes are clustered based on similarity in expression across the cell lines. The RNA data was used to cluster genes according to their expression across tissues. The new human gene database contains 43,162 genes, of which 21,306 are protein-coding and 21,856 are noncoding, and a total of 323,824 transcripts, for an average of 7.5 transcripts per gene. Several miRNA variants from different populations are known to be associated with an increased risk of rheumatoid arthritis (RA). Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, et al. (2014) identified compound heterozygosity for mutations in the RNPC3 gene: the first was a c.1420C-A transversion, resulting in a pro474-to-thr (P474T) substitution at a highly conserved residue in a turn position between the beta-3 strand and alpha-2 helix, and the second was a c.1504C-T transition . Non-coding DNA. 2019;47:D8538. Part of Filtering by the Yes annotation allows the retrieval of a non-redundant set of exons, coding exons and introns, respectively. At 181 million base pairs, chromosome 5 is the fifth largest human chromosome, accounting for 6% of the total. Would you like email updates of new search results? It contains 133 million base pairs of nucleotides, or over 4% of the total. Caracausi M, Ghini V, Locatelli C, Mericio M, Piovesan A, Antonaros F, Pelleri MC, Vitale L, Vacca RA, Bedetti F, et al. HHS Vulnerability Disclosure, Help PhyloCSF scores are calculated based on codon substitution frequencies. 99.4% of the bodys euchromatic DNA is located in chromosome 20. Python scripts provided with the software were run for the initial data pre-processing. Pseudogenes: 413 to 528. Piovesan A, Vitale L, Pelleri MC, Strippoli P. Universal tight correlation of codon bias and pool of RNA codons (codonome): the genome is optimized to allow any distribution of gene expression values in the transcriptome from bacteria to humans. "There are 3000 human proteins whose function is unknown," says Wood. The protein data covers 15318 genes (76%) for which there are available antibodies. Identification of minimal eukaryotic introns through GeneBase, a user-friendly tool for parsing the NCBI Gene databank. Then, the average expression per disease was further averaged as the disease baseline expression. (2018)). Protein-coding genes: 559 to 629 p-arm Partial list of the genes located on p-arm (short arm) of human chromosome 3: . Once the taq polymerase starts to replicate DNA, the probe is destroyed and fluorescent material is released . Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Main summarized data derived from the analysis of our updated and standard-formatted data sets are also provided here, while the data tables remain available for human genome studies. Finally, these data might be useful to design experiments for poorly characterized human genome regions, as in, for example, our current annotation effort of the recently defined highly restricted Down Syndrome critical region (HR-DSCR), which to date does not contain known genes [17], or to study transcription mechanisms such as alternative splicing or nonsense-mediated messenger RNA decay. Co-authors David Sweetser, MD, PhD, and Lauren Briere, MS, CGC, narrowed the search to a single nucleotide variant in the gene MIR145, a microRNA gene. Pseudogenes: 633 to 819. Mol Ther Nucleic Acids. How has the pathway and cytokine analysis been done? 2015;22:495503. Sci. volume12, Articlenumber:315 (2019) BMC Research Notes TNF - Encodes tumour necrosis factor, an immune molecule that has been a major drug target for inflammatory disease. Annotated by 9 databases (GeneCards, MalaCards, Ensembl/GENCODE, NONCODE, Ensembl, HGNC, LNCipedia, Expression Atlas, RefSeq). Non-coding RNA genes: 355 to 1,207 Hum Mol Genet. Protein-coding genes: 739 to 822 Non-coding RNA genes: 246 to 830 Pseudogenes: 590 to 738 Chromosome 9 accounts for between 4% and 4.5% of our DNA cells. (2021)). In the meantime, to ensure continued support, we are displaying the site without styles 2015;22:495503. Protein-coding genes: 45 to 73 2022 Apr 8;4(1):obac008. eCollection 2022. PubMed Central . All underlying images of immunohistochemistry stained normal tissues are available together with knowledge-based annotation of protein expression levels. 2023 Jan 25;31:398-410. doi: 10.1016/j.omtn.2023.01.010. Open Access Finally, we confirm that there are no human introns shorter than 30 bp. Epub 2006 Mar 9. The Cell Lines section contains information on genome-wide RNA expression profiles of human protein-coding genes in human cell lines. That leaves 2764 potential genes that may or may not be real. Proc. Finally, for each cell line, gene log2 fold changes were sorted from high to low, followed by the GSEA of the TCGA cohort elevated genes against the sorted gene list. Front Genet. Article Nature (2018)). Following the opening of the data sets in a spreadsheet application, users have easy access to the whole set of current reviewed/validated data about human nuclear protein-coding genes. Pseudogenes: 568 to 654. 2001;107:88191. Higher-order chromatin conformation forms a scaffold upon which epigenetic mechanisms converge to regulate gene expression [1, 2].Many genes are expressed in an allele-specific manner in the human genome, and this phenomenon is an important contributor to heritable differences in phenotypic traits and can be cause of congenital and acquired diseases including cancer [3, 4]. statement and An interactive network plot of the numbers of enriched and group enriched genes in all major organs and tissue types in the human body, connected to their respective enriched tissues. Also, DESeq2 normalized expression values were centered per gene as suggested. Provided by the Springer Nature SharedIt content-sharing initiative, Nature (Nature) -, Piovesan A, Vitale L, Pelleri MC, Strippoli P. Universal tight correlation of codon bias and pool of RNA codons (codonome): the genome is optimized to allow any distribution of gene expression values in the transcriptome from bacteria to humans. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in This section of the Human Protein Atlas focuses on the expression profiles in human tissues of genes both on the mRNA and protein level. Figure 1: Human species page. Homo sapiens (human) long intergenic non-protein coding RNA 32 (LINC00032) sequence is a product of NONHSAG051958.2, E, LINC00032, lnc-EQTN-1, ENSG00000291187.1 genes. The transcriptomics analysis covers 1055 human cell lines, corresponding to 27 cancer types, one non-cancerous group and one uncategorised group of cellines, and includes classification based on . The various subproteomes can be explored in this interactive database including numerous catalogs of protein-coding genes with detailed information regarding expression and localization of the corresponding proteins. The data sets are provided in standard, open format.xlsx. Mahley, R. W. et al. A number of 2685 genes are classified as brain elevated and 202 genes were only detected in the brain. Genomics. Next the team showed that the same proportion of human protein-coding genes remain a mystery. The reasons for the choice of the NCBI Gene database as a reference data source have been previously discussed in detail [6]. The UCSC genome browser database: 2019 update. Article The de novo origin of a new protein-coding gene from non-coding DNA is considered to be a very rare occurrence in genomes. Nature 381, 661666 (1996). But non-human genes do appear quite high on the list. The position of the longest intron is related to biological functions in some human genes. Identification of minimal eukaryotic introns through GeneBase, a user-friendly tool for parsing the NCBI Gene databank. These data might also be used in comparative genomic studies when compared to similar data sets generated from different species to uncover specific and significant differences in genome and gene organization. Abstract. The mRNA expression data is derived from deep sequencing of RNA (RNA-seq) from 256 different normal tissue types. It is expected that cell lines showing high concordance to the matched TCGA cancer type should present high log2 fold changes of the elevated genes of that TCGA cohort relative to the disease baseline expression. DNA Res. 2006 Jun;7(2):178-85. doi: 10.1093/bib/bbl003. Non-coding RNA genes: 251 to 1,046 Noncoding DNA does not provide instructions for making proteins. ISSN 0028-0836 (print). Non-coding RNA genes: 165 to 404 Bookshelf Members of this family maint ain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. Appended below is the summary of each of the chromosomes. Introduction: MicroRNAs (miRNAs) are small non-coding RNAs that play a key role in post-transcriptional modulation of individual genes' expression. Chromosome 13, with 3% of the bodys mapped human genome, is usually blamed for childhood obesity and delay in speech development. All the currently (alive/live qualification) available human nuclear gene entries were downloaded from NCBI Gene web site on January 5th, 2019 using the following text query: Homo sapiens [Organism] AND source_genomic [properties] AND alive [property]. 2019;47:D74551. Based on transcriptomics analysis across all major organs and tissue types in the human body, all putative 20090 protein coding genes have been classified with regard to abundance and distribution of transcribed mRNA molecules, including 10986 proteins showing a significantly elevated level of expression in a particular tissue or a group of related tissues and 8776 proteins detected in all organs and tissues. [International Human Genome Sequencing Consortium. Funded by the National Human Genome Research Institute (NHGRI), the ENCODE Project set out to systematically identify and catalog all functional elements parts of the genetic blueprint that may be crucial in directing how our cells function present in our DNA. Voshall A, Moriyama EN. About 4000 human protein-coding genes are not mentioned in any scientific publication at all. Data in the Transcripts.xlsx table include the same first five types of information provided in the Genes.xlsx table, plus RefSeq GenBank accession number for each transcript, length in bp of the whole transcript as well as of its 5 untranslated region UTR, coding sequence (CDS) and 3 UTR, number of exons and coding exons for that transcript, derived from the GeneBaseTranscripts table. Protein-coding genes: 417 to 496 volume551,pages 427431 (2017)Cite this article. Examples: HI0934, Rv3245c, ECs2657/ECs2658 For this, read counts for HPA and CCLE cell lines quantified by Kallisto were re-analyzed without filtering out the non-protein-coding genes to ensure a broadened coverage of cancer pathway responsive genes. FOIA The read counts of the 1055 cell lines were normalized by DESeq2 with respect to the size factor of each cell line and were further transformed by variance stabilizing transformation into log2 space. The results were represented as the normalized enrichment score (NES), with a positive value showing high consistency between a cell line and a disease-matched TCGA cohort. Pseudogenes: 381 to 400. Non-coding RNA genes: 328 to 992 National Center for Biotechnology Information, highly restricted Down Syndrome critical region. The following is a partial list of genes on human chromosome 3. 2013;101:282289. Extensive annotations were added to aid identification of differentially expressed genes, potential gene editing sites, and non-coding gene . The activity of 43 CytoSig cytokines was inferred based on the gene expression profile of the 1055 cell lines by the package CytoSig (Jiang P et al. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Accessibility Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, et al. The team followed up with a detailed molecular analysis which confirmed that the variant affects the expression of several cytoskeletal proteins and smooth muscle cell function. 2023 BioMed Central Ltd unless otherwise stated. Protein-coding genes: 996 to 1,111 Nucleic Acids Res. After that, for every cell line, we calculated the fold change of every gene relative to the disease baseline expression, followed by the log2 transformation of the fold change. The entire human mitochondrial DNA molecule has been mapped [1] [2] . You are using a browser version with limited support for CSS. Ensembl 2019. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Summary. This acrocentric chromosome measures 95 megabases long, and accounts for 3.5% of the human DNA. eCollection 2023 Mar 14. Protein-coding genes: 1,224 to 1,327 MCP and MC supervised the project. MeSH The two initial human genome papers reported 31,000 [ 2] and 26,588 protein-coding genes [ 3 ], and when the more . Pseudogenes: 574 to 785. Nature. 5, 15131523 (1991). Article Internet Explorer). Advances in the Exon-Intron Database (EID). Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S . Initial sequencing and analysis of the human genome. High-throughput sequencing technologies and bioinformatic tools significantly expanded our knowledge about ncRNAs, highlighting their key role in gene regulatory networks, through their capacity to interact with coding and non-coding RNAs, DNAs and . Morgan, T. H. Science 32, 120122 (1910). To test this, for the 27 cell line cancer types, gene expression was averaged per disease, resulting in the mean expression for each of the 27 cell line cancer types. Non-coding RNA genes: 325 to 1,199 Protein-coding genes: 646 to 719 Depending on the genome-sequencing center, OLNs are only attributed to protein-coding genes, or also to pseudogenes, and also to tRNA-coding genes and others. Biol Direct. Science. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. In addition, data can be exported in other formats and imported in other applications (database management systems, statistical software, genomic tools) for further analysis. You can filter the table results by gene type to show only protein-coding or non-coding genes, or search within the list of human genes by gene name or protein name. London: IntechOpen; 2018. p. 1536. All these kinds of analyses depend on the chosen gene entry subset, the RefSeq classification system and are subject to the accuracy of the input dataset. At that time, Consortium researchers had confirmed the existence of 19,599 protein-coding genes in the human genome and identified another 2,188 DNA segments that are predicted to be protein-coding genes. Around 890 diseases such as Alzheimer's, glaucoma and hearing loss have been linked to genetic disorders found in chromosome 1. Manage cookies/Do not sell my data we use in the preference centre. This lncRNA sequence is 2,913 nucleotides long and is found in Homo sapiens. We first performed a protein-centric transcriptomics scan to define a revised set of human secreted proteins (secretome) based on 19,670 protein-coding genes predicted by Ensembl ().For each protein-coding gene, all protein isoforms (splice variants) were annotated on the basis of the presence of a signal peptide, transmembrane regions, or both, and each protein isoform was classified as being . Dismiss. Measuring 82 megabases, chromosome 13 accounts for up to 3.5% of the human genome. Gene expression data were processed in the same way as for PROGENy analysis. Most of the sequences in the human genome do not code for proteins but generate thousands of non-coding RNAs (ncRNAs) with regulatory functions. List of human protein-coding genes page 4 covers genes SLC22A7-ZZZ3 NB: Each list page contains 5000 human protein-coding genes, sorted alphanumerically by the HGNC -approved gene symbol. In 2008, a draft of the complete human proteome was released from UniProtKB/Swiss-Prot: the approximately 20,000 putative human protein-coding genes were represented by one UniProtKB/Swiss-Prot entry each, tagged with the keyword 'Complete proteome' (now obsolete) and later linked to proteome identifier UP000005640.. RT-PCR. The clustering of 19023 genes expressed in tissues resulted in 89 expression clusters, which have been manually annotated to describe common features in terms of function and specificity. A well-known limit of genome browsers is that the large amount of genome and gene data is not organized in the form of a searchable database, hampering full management of numerical data and free calculations. The primary growth genes for cell divisions, which makes them vulnerable to cancers. Keywords: Tu Q, Cameron RA, Worley KC, Gibbs RA, Davidson EH. View/Edit Mouse. A key scientific priority is the functional characterization of lncRNAs, a major challenge in molecular biology that has encouraged many high-throughput efforts. More surprisingly, until about the year 2000, the fastest growing groups of human genes in the newly added literature were those that have never/rarely been reported about in previous years. CAS 2014;23:586678. These data allowed us to identify novel regulators of cambium activities and many non-coding RNAs that may tune the expression of protein-coding genes. The similarity between cell lines and the corresponding TCGA cohort was estimated by two different approaches: For all 1055 analyzed cell lines, the activity of a total of 14 cancer-related pathways were inferred using the PROGENy, a package that relies on biological data mining of publicly available data to obtain cancer-related pathway responsive genes for human and mouse (Schubert M et al. Google Scholar. Gao Y, Wang F, Wang R, Kutschera E, Xu Y, Xie S, Wang Y, Kadash-Edmondson KE, Lin L, Xing Y. Sci Adv. Protein-coding genes: 1,194 to 1,292 Ensembl 2019. Systematic reanalysis of partial trisomy 21 cases with or without Down syndrome suggests a small region on 21q22.13 as critical to the phenotype. Protein-coding genes: 706 to 754 The https:// ensures that you are connecting to the AMIA Annu. Other parameters such as gene, exon or intron mean and extreme length appear to have reached a stability that is unlikely to be substantially modified by human genome data updates, at least regarding protein-coding genes. Human Gene EEF1A2 (ENST00000706949.1) from GENCODE V43 . Chromosome 1 (human) Chromosome 2 (human) Chromosome 3 (human) Chromosome 4 (human) Chromosome 5 (human) Chromosome 6 (human) Chromosome 7 (human) Chromosome 8 (human) Chromosome 9 (human) Chromosome 10 (human) Up to 50 of the genes in chromosome 18 are involved in birth defects, so it is not a particularly popular chromosome. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory . Does the Pachytene Checkpoint, a Feature of Meiosis, Filter Out Mistakes in Double-Strand DNA Break Repair and as a side-Effect Strongly Promote Adaptive Speciation? The 985 cancer cell lines were analyzed for their representability of the corresponding TCGA disease cohorts. A well-known limit of genome browsers is that the large amount of genome and gene data is not organized in the form of a searchable database, hampering full management of numerical data and free calculations. The UMAP was generated by clustering genes based on expression patterns. Multiple evidence strands suggest that there may be as few as 19,000 human protein-coding genes. Among more than 60 different . Mitchell, J. Contains 249 million nucleotide base pairs, which amounts to 8% of the total DNA found in the human body. Thus, three tables in the open standard format .xlsx (Microsoft, Seattle, WA), Genes.xlsx, Transcripts.xlsx and Gene_Table.xlsx, are provided here. More information about the specific content and the generation and analysis of the data in the section can be found on the Methods Summary. Each tissue name is clickable and redirects to the selected proteome. -, Cunningham F, Achuthan P, Akanni W, Allen J, Amode MR, Armean IM, Bennett R, Bhai J, Billis K, Boddu S, et al. Epub 2023 Jan 20. The funding sources had no role in the design of this study and collection, analysis, and interpretation of data and in writing the manuscript. The genome-wide RNA expression profiles of human protein-coding genes in 18 single cell immune cell types are presented covering various B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells. Protein-coding genes: 739 to 822 Please enable it to take advantage of the complete set of features! Cite this article. Contains encoding instructions for Acylamino-acid-releasing enzyme, 5-azacytidine-induced protein 2 and protein C3orf23. The best assembled were COX1, COX3, and ND4L, as they have collected more than 90% of the protein-coding-gene length. Protein-coding genes: 516 to 555 Human Gene CCL25 (ENST00000680646.1) from GENCODE V43 . We identified 5,737 putative protein-coding genes that result from mRNA modified by human polymorphisms and have significant homology to known proteins.